National Drug Strategy
National Drug Strategy

Comorbidity of mental disorders and substance use: a brief guide for the primary care clinician

1.1 Management approaches

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In these guidelines, the quality of scientific evidence supporting statements concerning clinical practice is indicated by the following indications of 'level of evidence':

1.1.1 Level of Evidence

**** Strong - Systematic review of multiple randomised controlled trials (RCT) OR multiple RCTs with consistent findings.
*** Good - At least one RCT or multiple comparative (non-randomised) studies with consistent findings.
** Moderate - Any form of comparative (non-randomised) study.
* Some - Case series (single treatment group).
No Rating - No experimental studies - any statements are based on single case reports or clinical opinion/ expertise.

The system of rating the level of evidence draws on the system used by the National Health and Medical Research Council (NH&MRC) of Australia (A guide to the development, implementation and evaluation of clinical practice guidelines. Canberra: NH&MRC, 1999., and the Australian National Council on Drugs (ANCD) (Monograph 4).

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