Comorbidity of mental disorders and substance use: a brief guide for the primary care clinician
1.1 Management approaches
In these guidelines, the quality of scientific evidence supporting statements concerning clinical practice is indicated by the following indications of 'level of evidence':
1.1.1 Level of Evidence
**** Strong - Systematic review of multiple randomised controlled trials (RCT) OR multiple RCTs with consistent findings.
*** Good - At least one RCT or multiple comparative (non-randomised) studies with consistent findings.
** Moderate - Any form of comparative (non-randomised) study.
* Some - Case series (single treatment group).
No Rating - No experimental studies - any statements are based on single case reports or clinical opinion/ expertise.
The system of rating the level of evidence draws on the system used by the National Health and Medical Research Council (NH&MRC) of Australia (A guide to the development, implementation and evaluation of clinical practice guidelines. Canberra: NH&MRC, 1999. www.nhmrc.gov.au/publications/synopses/cp65syn.htm), and the Australian National Council on Drugs (ANCD) (Monograph 4).