Comorbidity of mental disorders and substance use: a brief guide for the primary care clinician
12.2 Do mental disorders predispose individuals to brain injury?
Mental disorders have been associated with an increased risk of brain injury(500).
Certain personality traits or disorders can result in a higher risk of brain injury. For example(501):
- Impulsivity and risk taking or novelty seeking combined with low harm-avoidance behaviour may result in head trauma from falls or road traffic accidents.
- Impulsivity may result in unintentional overdose in inexperienced substance users(354).
- Tendency towards violence as a means of resolving conflict will result in a greater likelihood of head trauma.


